DOES NSAID EXACERBATED RESPIRATORY DISEASE (N-ERD) ACCOMPANYING SEVERE ASTHMA AFFECT BIOLOGICAL TREATMENT RESPONSE? EFFICACY OF OMALIZUMAB AND MEPOLIZUMAB IN N-ERD

Introduction: Non-steroidal anti-inflammatory drug (NSAID)-exacerbated respiratory disease (N-ERD) accompanies severe asthma in about 15% of the patients and may adversely affect the prognosis.Omalizumab and mepolizumab are biologics used in patients with severe asthma.The objective of this study is to assess the respiratory improvements, after the

Abstract Background Circular RNAs (circRNAs) play diverse roles in different biological and physiological environments and are always Commercial Door Hardware expressed in a tissue-specific manner.Especially, circRNAs are enriched in the brain tissues of almost all investigated species, including humans, mice, Drosophila, etc.Although circRNAs were

Abstract Background Understanding human genetic influences on the gut microbiota helps elucidate the mechanisms by which genetics may influence health outcomes.Typical microbiome genome-wide association studies (GWAS) marginally assess the association between individual genetic variants and individual microbial taxa.We propose a novel approach, the

We previously demonstrated endocytosis of KCa2.3 is caveolin-1-, dynamin II- and Rab5-dependent.KCa2.3 then enters Rab35/EPI64C- and RME-1-containing recycling endosomes and is returned to the plasma membrane (PM).Herein, we report on the mechanism by which KCa2.3 is inserted into the PM during recycling and following exit from the Golgi.We demonst

The neglected tropical diseases (NTDs) are characterized by their tendency to cluster within groups of people, typically the poorest and most marginalized.Despite this, measures of clustering, such as within-group correlation or between-group heterogeneity, are rarely reported from community-based studies of NTD risk.We describe a general contextua